Return-Path: Delivered-To: diana@transocean.com Received: from vps.transocean.com by vps.transocean.com (Dovecot) with LMTP id qZlfO8itJVmnUQAAInt2oQ for ; Wed, 24 May 2017 08:59:05 -0700 Return-path: Envelope-to: diana@transocean.com Delivery-date: Wed, 24 May 2017 08:59:05 -0700 Received: from [69.30.197.252] (port=34923 helo=mail.newestonlineoilspecials.com) by vps.transocean.com with esmtp (Exim 4.89) (envelope-from ) id 1dDYgg-0005SH-Vk for diana@transocean.com; Wed, 24 May 2017 08:59:04 -0700 DKIM-Signature: v=1; a=rsa-sha1; c=relaxed/relaxed; s=dkim; d=newestonlineoilspecials.com; h=Date:From:To:Subject:MIME-Version:Content-Type:List-Unsubscribe:Message-ID; i=cbdgummies@newestonlineoilspecials.com; bh=GlxX1NKSwuqJRZNKT6k/tuBa0kk=; b=iVehw4xqgoEf1zxjfoiEnMgYnW1d4ELnVY1RSbeDMNamPhhwj794YF0AsIic5ruUSW257iCYsmQE yLmLbUwMn5sc4UbumvC3qyGopr8kpL+cmSlW20JoDT14o1qexhZxMx1RZae+0JNh1wX8SYl7h1Zg FekIlf6gAX04hIxqd0Y= DomainKey-Signature: a=rsa-sha1; c=nofws; q=dns; s=dkim; d=newestonlineoilspecials.com; b=DYojAV8IrB4LfwuMU/EKGsW695oQlvj4iHZjgshxizVsuYuehPAXDD7PxWjzvhvhHlzb5XPTXqLP wJ7Pz2Zhs1ufAlRSPhASW4ovXdoyZLmkJxdsaOqxAKNYYGpsYlvRGmnRzvP5ghuahTGII7FHdKod 5bfrM4samxBlGNMiTPk=; Received: by mail.newestonlineoilspecials.com id h4n47e0001gu for ; Wed, 24 May 2017 13:46:21 -0400 (envelope-from ) Date: Wed, 24 May 2017 13:46:21 -0400 From: CBDGummies To: MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="----=_Part_22_1705143968.1495641137128" List-Unsubscribe: Message-ID: <0.0.0.2.1D2D4B5A7EA8E12.2E2D1E@mail.newestonlineoilspecials.com> X-Spam-Status: Yes, score=4.2 X-Spam-Score: 42 X-Spam-Bar: ++++ X-Spam-Report: Spam detection software, running on the system "vps.transocean.com", has identified this incoming email as possible spam. The original message has been attached to this so you can view it or label similar future email. If you have any questions, see root\@localhost for details. Content preview: CBD-Gummies CBD-Oil Gummies Now Legal in ALL 50-States! No.Prescrip.tion-Necessary. From reducing anxiety, nausea, vomiting and depression to relieving aches and pains and even fighting cancer-cells, CBD-Oil (Cannabidiol-CBD) can assist in nearly any-ailment and now it comes in an easy to-digest Gummy-Form! [...] Content analysis details: (4.2 points, 3.0 required) pts rule name description ---- ---------------------- -------------------------------------------------- 0.0 URIBL_BLOCKED ADMINISTRATOR NOTICE: The query to URIBL was blocked. See http://wiki.apache.org/spamassassin/DnsBlocklists#dnsbl-block for more information. [URIs: newestonlineoilspecials.com] -0.0 SPF_PASS SPF: sender matches SPF record 0.8 BAYES_50 BODY: Bayes spam probability is 40 to 60% [score: 0.5000] 0.0 HTML_MESSAGE BODY: HTML included in message 0.7 MIME_HTML_ONLY BODY: Message only has text/html MIME parts 0.8 MPART_ALT_DIFF BODY: HTML and text parts are different 0.0 MIME_QP_LONG_LINE RAW: Quoted-printable line longer than 76 chars -0.1 DKIM_VALID Message has at least one valid DKIM or DK signature 0.1 DKIM_SIGNED Message has a DKIM or DK signature, not necessarily valid -0.1 DKIM_VALID_AU Message has a valid DKIM or DK signature from author's domain 2.0 RDNS_NONE Delivered to internal network by a host with no rDNS 0.0 MIME_HTML_ONLY_MULTI Multipart message only has text/html MIME parts 0.0 T_REMOTE_IMAGE Message contains an external image X-Spam-Flag: YES Subject: ****SPAM**** Newly Legal-CBD Oil Now Comes in Easy to Digest Gummie-Form. ------=_Part_22_1705143968.1495641137128 Content-Type: text/html; charset=us-ascii Content-Transfer-Encoding: quoted-printable =20 =20 =20 =20 =20 CBD-Gummies=20 =20 =20 =20 =20 =20 =20 =20
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=20 Cannabis sativa L. preparations have been used in medici= ne for millenia. However, concern over the dangers of abuse led to the bann= ing of the medicinal use of marijuana in most countries in the 1930s. Only = recently, marijuana and individual natural and synthetic cannabinoid recept= or agonists and antagonists, as well as chemically related compounds, whose= mechanism of action is still obscure, have come back to being considered o= f therapeutic value. However, their use is highly restricted. Despite the m= ild addiction to cannabis and the possible enhancement of addiction to othe= r substances of abuse, when combined with cannabis, the therapeutic value o= f cannabinoids is too high to be put aside. Numerous diseases, such as anor= exia, emesis, pain, inflammation, multiple sclerosis, neurodegenerative dis= orders (Parkinson's disease, Huntington's disease, Tourette's syndrome, Alz= heimer's disease), epilepsy, glaucoma, osteoporosis, schizophrenia, cardiov= ascular disorders, cancer, obesity, and metabolic syndrome-related disorder= s, to name just a few, are being treated or have the potential to be treate= d by cannabinoid agonists/antagonists/cannabinoid-related compounds. In vie= w of the very low toxicity and the generally benign side effects of this gr= oup of compounds, neglecting or denying their clinical potential is unaccep= table - instead, we need to work on the development of more selective canna= binoid receptor agonists/antagonists and related compounds, as well as on n= ovel drugs of this family with better selectivity, distribution patterns, a= nd pharmacokinetics, and - in cases where it is impossible to separate the = desired clinical action and the psychoactivity - just to monitor these side= effects carefully. Cannabis sativa L. preparations, such as marijuana, has= hish, and dagga, have been used in medicine for millenia.1 Investigations i= nto the chemistry of Cannabis began in the mid-19th century, following a ma= jor trend in chemical research at the time, which centered on the quest for= active natural products. Numerous alkaloids were isolated in pure form or = partially characterized. Morphine, cocaine, strychnine, and many others wer= e purified and used in medicine. However, most of the terpenoids - a major = class of secondary plant metabolites, to which the plant cannabinoids also = belong - were not isolated until the end of the century or even much later,= and in many cases their purity was doubtful.

In 1840, Schlesinger was apparently the fi= rst investigator to obtain an active extract from the leaves and flowers of= hemp.2 A few years later, Decourtive described the preparation of an ethan= ol extract that on evaporation of the solvent gave a dark resin, which he n= amed â??cannabin.â?=9D 3 For a detailed history of early Cannab= is research see ref 4. The chemical research on the plant cannabinoids and = their derivatives over nearly two centuries is described in ref 5. It was, = however, not until 1964 that ?9-tetrahydrocannabinol (?9-THC), the major ps= ychoactive component of Cannabis, was isolated in pure form and its structu= re was elucidated.6 Shortly thereafter it was synthesized and became widely= available. These chemical advances led to an avalanche of publications on = ?9-THC, as well as on cannabidiol (CBD), a nonpsychoactive plant cannabinoi= d.7 However, concern about the dangers of abuse led to the banning of marij= uana and its constituents for medicinal use in United States and many other= countries in the 1930s and 1940s. It took decades until cannabinoids came = to be considered again as compounds of therapeutic value, and even now thei= r uses are highly restricted. Here we present an overview of the addictive = and side effects of cannabinoids vs their therapeutic potential. Marijuana = may produce mild dependence in humans.8-12 This was shown to depend on the = personality type of the addicts,13 and can be successfully reversed by abst= inence or treated by cognitive-behavioral therapy,14 without the occurrence= of major withdrawal symptoms. Cannabinoids act on brain reward processes a= nd reward-related behaviors by a mechanism similar to that found with other= addictive drugs. In animal models they enhance electrical brain-stimulatio= n reward in the core meso-accumbens reward circuitry of the brain and neura= l firing of a core dopamine (DA) component and thus elevate DA circuit. In = the reward-relevant meso-accumbens DA circuit. In some animal models they p= roduce conditioned place preference (CPP) and self-administration.15,16 Oth= er studies, however, find THC to be a poor reinforcer, with no or little se= lf-administration.17

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The abuse of other substances is influence= d by the cannabinoids. The cannabinoid system is involved in alcohol-consum= ption behavior. Cannabinoid CB1 receptor agonists have been found to specif= ically stimulate alcohol intake and its motivational properties in rats.18 = The high ethanol preference of young mice is reduced by the cannabinoid rec= eptor 1 (CB1) antagonist SR141716A (rimonabant) to levels observed in their= CB1 knockout littermates.19 Dopamine release induced by ethanol in brain w= as reduced by SR141716A,20 which can explain in part the antiaddictive effe= ct of the drug. Cocaine is another substance of abuse in whose acquisition = and consolidation cannabinoids may be involved. High prevalence of alcohol = dependence and cannabis dependence can be found in patients with cocaine de= pendences.21 Marijuana smoking increases plasma cocaine levels and subjecti= ve reports of euphoria in male volunteers.22,23 Furthermore, a recent genet= ic study found an association between an n triplet repeat polymorphism in t= he CB1 encoding CNR1 gene with cocaine addiction in the African-Caribbean p= opulation.24 In another study it was found that withdrawal from repeated ac= cess or exposure to cocaine and then a reinstatement of cocaine-seeking beh= avior or a sensitized locomotor response to a single cocaine challenge, res= pectively, was potently reduced by pretreatment with rimonabant.25 Similarl= y, acute administration of rimonabant blocked expression of nicotineinduced= conditioned place preference.26 Rimonabant also reduces nicotine self-admi= nistration, and may be effective not only as an aid for smoking cessation, = but also in the maintenance of abstinence.27 As the endocannabinoid system = plays a role in nicotine addiction,28 the potential of cannabinoid antagoni= sts to treat it is self-evident.29-31 Opiate and CB1 receptors are coexpres= sed in the nucleus accumbens and dorsal striatum, and the interaction betwe= en the two systems is well known.32 The reinforcing properties of morphine = and the severity of the withdrawal syndrome are strongly reduced in CB1-kno= ckout mice33; this observation opens an opportunity to treat opiate addicti= on with rimonabant, as noted with alcohol, cocaine, and nicotine addiction.=

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